Our Primary Investigator
Dr. Patrick Shiu PhD
Copyright 2007 University of Missouri. All Rights Reserved.
Welcome to Our Website
Meiotic Silencing by Unpaired DNA - a new RNAi phenomenon?
Our research interest is directed toward sexual development in fungi. It is very appealing to use Neurospora as a model organism for sexual development, since each phase in its sexual cycle is discrete and well-defined, and that mutants affecting individual step have been identified (with over 200 sexual mutants already isolated). We have demonstrated that meiotic silencing by an ectopic transgene can be a quick and easy tool for investigating the role of genes in meiosis and spore development, including genes for which a knockout construct would surely be lethal in vegetative life. With the recent completion of the Neurospora genome project, it would be relatively easy to identify genes that are required for meiosis and sexual development.
Current Publication
Raju NB, Metzenberg RL, Shiu PK.
Genetics. 2007 May;176(1):43-52. Epub 2007 Mar 4.
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