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How do individual neurons and neural networks balance between plasticity and stability in the nervous system?

Welcome to the Schulz Lab in the Department of Biological Sciences and Interdisciplinary Neuroscience Program at the University of Missouri. Our lab focuses on how plasticity and stability are balanced in individual neurons and neural networks by studying natural network outputs as well as responses to injury and removal of network inputs.

Using electrophysiology,molecular biology, and computer modeling techniques, we study regulation of ion channel proteins and how this influences neuronal excitability. We use central pattern generator (CPG) and autonomic nervous system networks at the single neuron level to determine how these networks function and respond to injury. Using this approach, we can investigate not only the effects at the single cell level, but also the influence that changes in single neurons has on the network activity as a whole.

This work has implications not only for understanding how networks maintain functional output, but also what goes wrong when these networks fail, as is the case with some diseases and injuries that affect the circuitry of the brain and spinal cord.

Recent Publications

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Temporal S, Lett KM, Schulz DJ (2014) Activity-dependent feedback regulates correlated ion channel mRNA levels in single identified motor neurons. Current Biology 24: 1899-1904. .

Garcia VB, Garcia ML, Schulz DJ (2014) Quantitative expression profiling in mouse spinal cord reveals changing relationships among channel and receptor mRNA levels across postnatal maturation. Neuroscience 277C: 321-333.