Research Description:
A Dictyostelium discoideum genetic approach was used to clone the sphingosine+ phosphate lyase gene, which encodes the enzyme that catalyses sphingosine-1-phosphate degradation. Current research is focused on overexpression of the gene to study the relationship between sphingolipids metabolism and the resistance fo anticancer drugs in multicellular slime mold.
Publications:
Min, J., Stegner, A.L., Alexander, H. and Alexander, S. (2004). Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. Eukaryotic Cell. 3:795-805.
Effect of Tocopherols on proliferation of HepG2 cells. Hyg. Res. 2002
Effect of Tocopherols on apoptosis of HepG2 cells. Hyg. Res. 2002
Relativity Research and Analysis on Psychology Response of Chinese Cancer Patients. Journal of Zhonghua Nursing, 1999 (3):180-182
Nutrition for The Middle-age. Shanghai Science Press, Shanghai, 2001.
Nutrition for The Children. Shanghai Science Press, Shanghai, 2001.
Nutrition for The Female. Shanghai Science Press, Shanghai, 2001.
